I had this problem but I found a fix that worked and it never happened again. Are you running an AMD Graphics card? By chance, are you aiming when this happens? if so its probably caused by Raptr ingame app. The AMD Gaming Evolved has an in game overlay and the key combo in Watch dogs seems to lock because of it. The simple answer is close Raptr befor starting the game but I like it at it is recording my in game hours. So you can keep AMD Raptr running all you need to do is un tick the little box above the "Launch Game" button to disable the "In-game apps". Now you dont have to worry about remembering to close Raptr each time you start up Windows.
Hope this helps
For some reason the customize controls settings is broken. Under the "In Vehicle" setting I have 4 blank settings? and I can map them to anything thus preventing me from giving myself new controls that my fingers can actually reach in time when I need them instead of having to look at my key bored every time wasting time and probably getting shot. Does anyone else have this issue? Is it like something I can only do in game? Or what? Because I'm trying to do it in the main menu. thank for any responses.Originally Posted by xXMark-84Xx Go to original post