Read and follow this?
https://forums.ubisoft.com/showthrea...ration-and-FAQ
Heya, MasonChile and rcole_sooner! I am sorry to hear that you have been unable to play Rocksmith so far, and I appreciate you for sharing that thread! If you are still noticing issues, I will be happy to look into this further with you. To start, you mentioned that you are using Windows 10. In that case, I suggest that you attempt to use Windows Compatibility Mode and then let me know if that helps!