I opted for the most radical approach by uninstalling the game and removed all files in the 'Documents/My Games' folder from The Division 2. Then installed the game again (took few hours) but was able to complete all 9 check points of the current manhunt without any problems. Had brief freezes of 2-4 seconds 4 times but other then that it all worked well. So for those that are having a lot of issues like I had since yesterday this might work for you too. Going to try again later today and clear the other parts of the manhunt target.
Thank you for the efforts of Ubisoft team. Just to feedback my observation after the latest version upgrade. I hadn't severely crash issues after disabled the in-game overlay option in Ubisoft Connect, some crashes could be solved by rebooting my PC. After the latest upgrade, it crashed several times with the workarounds before. I had go back to settings to enable the DX12 and changed the display mode from Full Screen to Full Screen (Windows), and it looks the game ran smoothly. I do believe there are some minor issues couldn't be addressed with the new fixes, and reinstall the game may help as all configurations can be reset.