Just use the guns you want to use to make the game harder......
The main thing that makes the game easier is the bonus health and consumables. Honestly, if you just want to use Bows and 1911 pistols then do so....it is your choice and you don't have to use any gun at any time that you don't want to.
If you want to do a Infamous run, no added health, and the above Bows and 1911s and throwables, then go ahead do it, it is actually a fun run, and not that hard all in all. But it would usually take two runs, first to go through Hard with a new character and NOT take any perks for Health, and then you can do Infamous on the next run. If you are running on PC, then find the saves files and copy them so you can then swap them out to have different characters setups.
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