I have had a complete computer freeze up.
Ctrl - Alt - Del doesn't even get me out of the problem.
I have to turn my computer off and restart.
System:
Windows 10/64-bit
Ryzen 5 3600x
5700 XT
16gb ram
Latest AMD driver
Resolution: 2560 x 1440
Ultra settings.
For the longest while it ran fine, then during some missions (I forget which), it crashed 3x. Not in the same area, but during the same attempted mission.