These are the issues I've had while playing the Open Beta:
-Drone won't deploy sometimes. A few times I've had to fast travel back to a bivouac camp to fix it.
-Have to hold down the B button a few times before character will slide down a ladder.
-Not showing I picked up ammo off enemies.
-Stuck in conversation with person for intel. Had to restart game.
-Stuck at level 10, when clearly I should be higher. Not gaining skill points.
-Character will constantly pick up an item until I move.
-Character will reload weapon even though I have a full clip.
-Weapons crates in buildings that I can't access.
-Preparations not activating.
-Shopkeeper in Erewhon, no voice.
Have about 30 hours in the Open Beta so far, and these are the issues that I've come across.