I think the next Far Cry should have brutal friendly NPCs, if you get violent on the 'innocent' they beat the player down ruthlessly, stop trading with them, force them to scavenge gear from the dead, throw them into confinement and even hunt them until some 'karma' type balance is reached where they forgive the unrestrained sadism of many players.

I can see how that would encourage violence against the resistance in Far Cry 5 or New Dawn, so it has to be some world out of balance instead of the "oh we're just helpless citizens", it has to be that the NPCs have the power or powerful allies and the player is their powerless plumber trudging through the sludge mission by mission until they too have power, and then it can be total war where only the people you rescue from near death or rescue of their loved ones or defeat their enemies support you in anyway until the favor is repaid and then they say something like "My debt to you is paid in full, when next we meet do not expect mercy."

Ubisoft is missing their own tights, capes and double crossing creeps super hero franchise that Far Cry is right on the border of.

Cybernetics, chemical enhancements, bioogical reorganization, symbiotes, alien technology, maybe even magic could all play a role and be customization options instead of and/or along side weapon/loadout customization. Factions/Motivating characters can all provide these options or missions to reach these options, and there could be draw backs like get laser shooting eyes, but lose your echo location ability, or acquire telekinetic take down ability but be susceptible to friend/foe identification overrides or mental destabilization alarms.

If the society is mostly robotics/cyborgs/telepaths/demon possessed/haunted people and such then this can be carried out in a way that would make sense when the player double crosses the NPCs and starts putting bullets, punches or plasma in the people they are meant to help or at least treat with reasoanble respect.
They wouldn't know that the shop keeper is a robot or has one in the back room closet until they knock them down and then "wooot wooot woot unlicensed violence in sector 7, violator identified! Capture or Kill Orders Cleared and Certified by Central Citizen Council."

Ubisoft just needs some colorful leotards, a lot of coffee, and then to lock themselves in mortal combat in the break room to sort out this wonderful mess of an adventure. May the best X win.