Hi 😊
I think a have the solution for the Settlers game crashing. Savegames and other Settlers files are placed in the Document folder. If you have activated the Windows 10 Ransomware protection, it will not allow uplay.exe and settlers.exe to write to Document folder.
Open Ransomeware protection and allow uplay.exe and settlers.exe to write – google: windows 10 ransomware protection allow app
Cheers Michael