Active Elemental Effect
With the Global Modifier, you always have one of three elemental effects active. You can have Burn, Bleed and Gas and depending on what is active, you do a different kind of elemental damage. You can switch the elemental effect by reloading your weapon. The Elemental Effects are weapon specific, so you can have different effects on each weapon.
Elemental Effect Rotation
When you reload your weapon, the elemental effects rotate always in the same order: Burn, Bleed, and Gas. Keep that in mind when you reload and when you have react to multiple enemies. Also keep different effects on both weapons, so that you can push the NPCs back.
NPC Buff/Debuff
When the second an third modifiers are active, each NPC is vulnerable to a specific set of Elemental Damage and resistant against others. When they are resistant, the icon is greyed out, you will do a lot less damage and they do a lot more damage to you. When the NPCs are vulnerable, the icons are colored out and you can tear them down fast - even on legendary difficulty.
The trick is, you have to match the elemental effect on your agent, to the icon above the NPC - only, in this case, you do enough damage to tear them down before they kill you.
Brutal Onslaught - damage bonus (Smart Ammo)
When two or more group members kill a vulnerable enemy within two seconds, each member can reload to gain a damage bonus for a single clip. That bonus is represented by a skull that appears next to your weapon. The bonus is weapon specific and will disappear as soon as you reload that weapon or the magazine is empty. As long as the bonus is active, you can do damage against any NPC and you are not limited to one element.
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