Hey there!
I really don't want to spoil anything for you and would prefer for you to discover it yourself, but one thing that comes to mind when I read your post is:Originally Posted by YouMadOrNahw Go to original post
Spoiler: Show
/CJ
My friend and I were both missing two quests in John's region. While the "YES" sign quest was one of them, it seems if you don't do the "Valley Armed Convoy" quest at the proper time it will vanish and you won't be able to complete it - I suspect before killing John. Friend has the same issue, 100%'d the rest of the game. Annoying.