I had this exact same problem with Rainbow Six: Siege and Verify Game Files found some corrupted files. Download new files and it fixed the problem. Tried to verify files with Primal and it said All Files Verified. Just downloaded the game last night, started this morning and the mouse will not navigate to the right hand third of the screen. I can't even use the Options to verify or change resolution.
Windows 10 with 2017 Fall Creators Update, 16 GB Ram, plays all AAA games smooth as glass. Long story short: just bought it, can't play it. Any assistance would be greatly appreciated.